Tuesday, May 23, 2017

ACE inhibitors / hi blood pressure

https://www.rainbow.coop/…/angiotensin-converting-enzyme-a…/
ACE inhibitors have been found in the following: maize, wheat, rapeseed (canola,) soybean, buckwheat, sunflower, sorghum, milk, cheese, meat, eggs, and fish. Bioactive peptides derived from garlic (Allium sativum) can lower blood pressure.
Peptides can be flavorful or bitter. Peptides can be larger, up to 51 amino acids. These longer chains can be absorbed through the intestinal wall and are bioactive. The peptide activity is reduced in longer chains. Shorter chain di- and tri-peptides are absorbed more rapidly than free amino acids.
Commercially, acid hydrolysis or enzymatic digestion can release peptides. The enzymatic method is more satisfactory and easier to control. Microbial fermentation produces peptides. Lactic acid bacteria and Bifidobacteria are most commonly used.
Nitric oxide can, also, inhibit ACE.
CONCLUSION: Biologically active peptides can be absorbed through the intestine and are biologically active in the body. Short chain peptides, produced by enzymatic and bacterial processes, can act as ACE inhibitors and can lower blood pressures.

http://www.sciencedirect.com/science/article/pii/S1043661816307848

Punica granatum L. (Pomegranate) has been claimed to provide several health benefits. Pomegranate juice is a polyphenol-rich fruit juice with high antioxidant capacity. Several studies suggested that pomegranate juice can exert antiatherogenic, antioxidant, antihypertensive, and anti-inflammatory effects. Nevertheless, the potential cardioprotective benefits of pomegranate juice deserve further clinical investigation. To systematically review and meta-analyze available evidence from randomized placebo-controlled trials (RCTs) investigating the effects of pomegranate juice consumption and blood pressure (BP). A comprehensive literature search in Medline and Scopus was carried out to identify eligible RCTs. A meta-analysis of eligible studies was performed using a random-effects model. Quality assessment, sensitivity analysisand publication bias evaluations were conducted using standard methods. Quantitative data synthesis from 8 RCTs showed significant reductions in both systolic [weighed mean difference (WMD): −4.96 mmHg, 95% CI: −7.67 to −2.25, p < 0.001) and diastolic BP (WMD: −2.01 mmHg, 95% CI: −3.71 to −0.31, p = 0.021) after pomegranate juice consumption. Effects on SBP remained stable to sensitivity analyses. Pomegranate juice reduced SBP regardless of the duration (>12 wks: WMD = −4.36 mmHg, 95% CI: −7.89 to −0.82, p = 0.016) and <12 95="" and="" ci:="" consumed="" dose="" mmhg="" nbsp="" p="" to="" wks:="" wmd="">240 cc: WMD = −3.62 mmHg, 95% CI: −6.62 to −0.63, p = 0.018) and <240 95="" cc:="" ci:="" day="" doses="" juice="" mmhg="" nbsp="" p="" per="" pomegranate="" to="" whereas="" wmd="">240 cc provided a borderline significant effect in reducing DBP. The present meta-analysis suggests consistent benefits of pomegranate juice consumption on BP. This evidence suggests it may be prudent to include this fruit juice in a heart-healthy diet. 


<12 95="" and="" ci:="" consumed="" dose="" mmhg="" nbsp="" p="" to="" wks:="" wmd=""><240 95="" cc:="" ci:="" day="" doses="" juice="" mmhg="" nbsp="" p="" per="" pomegranate="" to="" whereas="" wmd="">
The researchers took a look at the average systolic and diastolic blood pressure levels in those who were either drinking pomegranate juice or not drinking it. The systolic blood pressure levels are the higher number — the one around 120 millimeters of mercury (mmHg)— and the lower number is the diastolic number (80mmHg on average).
Read more at http://www.businessinsider.sg/pomegranate-juice-health-benefits-heart-teeth-blood-pressure-2017-4/2/#pEuE0JTYTmrRweAz.99
 

Tuesday, May 23, 2017

ACE inhibitors / hi blood pressure

https://www.rainbow.coop/…/angiotensin-converting-enzyme-a…/
ACE inhibitors have been found in the following: maize, wheat, rapeseed (canola,) soybean, buckwheat, sunflower, sorghum, milk, cheese, meat, eggs, and fish. Bioactive peptides derived from garlic (Allium sativum) can lower blood pressure.
Peptides can be flavorful or bitter. Peptides can be larger, up to 51 amino acids. These longer chains can be absorbed through the intestinal wall and are bioactive. The peptide activity is reduced in longer chains. Shorter chain di- and tri-peptides are absorbed more rapidly than free amino acids.
Commercially, acid hydrolysis or enzymatic digestion can release peptides. The enzymatic method is more satisfactory and easier to control. Microbial fermentation produces peptides. Lactic acid bacteria and Bifidobacteria are most commonly used.
Nitric oxide can, also, inhibit ACE.
CONCLUSION: Biologically active peptides can be absorbed through the intestine and are biologically active in the body. Short chain peptides, produced by enzymatic and bacterial processes, can act as ACE inhibitors and can lower blood pressures.

http://www.sciencedirect.com/science/article/pii/S1043661816307848

Punica granatum L. (Pomegranate) has been claimed to provide several health benefits. Pomegranate juice is a polyphenol-rich fruit juice with high antioxidant capacity. Several studies suggested that pomegranate juice can exert antiatherogenic, antioxidant, antihypertensive, and anti-inflammatory effects. Nevertheless, the potential cardioprotective benefits of pomegranate juice deserve further clinical investigation. To systematically review and meta-analyze available evidence from randomized placebo-controlled trials (RCTs) investigating the effects of pomegranate juice consumption and blood pressure (BP). A comprehensive literature search in Medline and Scopus was carried out to identify eligible RCTs. A meta-analysis of eligible studies was performed using a random-effects model. Quality assessment, sensitivity analysisand publication bias evaluations were conducted using standard methods. Quantitative data synthesis from 8 RCTs showed significant reductions in both systolic [weighed mean difference (WMD): −4.96 mmHg, 95% CI: −7.67 to −2.25, p < 0.001) and diastolic BP (WMD: −2.01 mmHg, 95% CI: −3.71 to −0.31, p = 0.021) after pomegranate juice consumption. Effects on SBP remained stable to sensitivity analyses. Pomegranate juice reduced SBP regardless of the duration (>12 wks: WMD = −4.36 mmHg, 95% CI: −7.89 to −0.82, p = 0.016) and <12 95="" and="" ci:="" consumed="" dose="" mmhg="" nbsp="" p="" to="" wks:="" wmd="">240 cc: WMD = −3.62 mmHg, 95% CI: −6.62 to −0.63, p = 0.018) and <240 95="" cc:="" ci:="" day="" doses="" juice="" mmhg="" nbsp="" p="" per="" pomegranate="" to="" whereas="" wmd="">240 cc provided a borderline significant effect in reducing DBP. The present meta-analysis suggests consistent benefits of pomegranate juice consumption on BP. This evidence suggests it may be prudent to include this fruit juice in a heart-healthy diet. 


<12 95="" and="" ci:="" consumed="" dose="" mmhg="" nbsp="" p="" to="" wks:="" wmd=""><240 95="" cc:="" ci:="" day="" doses="" juice="" mmhg="" nbsp="" p="" per="" pomegranate="" to="" whereas="" wmd="">
The researchers took a look at the average systolic and diastolic blood pressure levels in those who were either drinking pomegranate juice or not drinking it. The systolic blood pressure levels are the higher number — the one around 120 millimeters of mercury (mmHg)— and the lower number is the diastolic number (80mmHg on average).
Read more at http://www.businessinsider.sg/pomegranate-juice-health-benefits-heart-teeth-blood-pressure-2017-4/2/#pEuE0JTYTmrRweAz.99